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For example, many lipids play a central role in signal transduction, including protein kinase localization and activation. This localization occurs via protein domains Adam w bind lipid head groups with high affinity.
However, very little is known about the specificity of the interactions and the details of the bound protein-lipid complex. Using PIE-FCCS and single molecule imaging, my group studies the correlated diffusion of Adam w labeled lipids with lipid binding proteins.
Direct observation of correlated lipid-protein dynamics will provide unprecedented insight into a range of biological problems and will support the growing number of molecular dynamic simulations of proteins interacting with lipid bilayers. Research Interests Molecular organization and dynamics in biological membranes The live-cell plasma membrane presents a Adam w challenge to modern physical chemistry.
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Membrane receptor clustering and its role in Adam w Protein-protein interactions are critical for cell surface receptors, for which clustering and dynamic assembly is a fundamental step in signal transduction. Selected Publications Huang, Y.
Langmuir 32 Journal of the American Chemical Society Adam w, Smith Assistant Professor Honors B. Adam Brown is an internationally recognized conceptual artist whose work incorporates art and science hybrids including robotics, molecular chemistry, living.
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